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Asymmetric synthesis of fluoroalkylated N,O-ketals via an organocatalytic dehydration/aminalization/aza-Michael desymmetrization

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Abstract

A chiral C–O bond delivering chiral N,O-ketals was developed via an organocatalytic dehydration/aminalization/aza-Michael desymmetrization. A variety of fluoroalkylated N,O-ketals can be obtained with excellent yields (up to 98%) and good to excellent enantioselectivities (up to 92%).

Graphical abstract: Asymmetric synthesis of fluoroalkylated N,O-ketals via an organocatalytic dehydration/aminalization/aza-Michael desymmetrization

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Publication details

The article was received on 24 Dec 2018, accepted on 08 Feb 2019 and first published on 12 Feb 2019


Article type: Research Article
DOI: 10.1039/C8QO01397G
Citation: Org. Chem. Front., 2019, Advance Article

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    Asymmetric synthesis of fluoroalkylated N,O-ketals via an organocatalytic dehydration/aminalization/aza-Michael desymmetrization

    Y. Gui, X. Liang, Y. Li, K. Li, Z. Zha and Z. Wang, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C8QO01397G

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