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Fischernolides A–D, four novel diterpene-based meroterpenoid scaffolds with antitumor activities from Euphorbia fischeriana

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Abstract

Fischernolides A–D (1–4), four meroterpenoids based on diterpene and acylphloroglucinol, possessing an unprecedented 28-carbon skeleton with a novel scaffold, were isolated from the roots of Euphorbia fischeriana. Their structures and absolute configurations were determined by comprehensive chemical analyses including spectroscopic techniques, electronic circular dichroism (ECD) spectroscopy, and single crystal X-ray diffraction experiments. The possible biogenetic pathway to generate 1–4 through aldol condensation was also proposed. Compound 2 showed significant cytotoxicity and can induce the apoptosis of MCF-7 and Bel-7402 cell lines by caspase activation.

Graphical abstract: Fischernolides A–D, four novel diterpene-based meroterpenoid scaffolds with antitumor activities from Euphorbia fischeriana

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Publication details

The article was received on 20 Dec 2018, accepted on 09 Feb 2019 and first published on 15 Feb 2019


Article type: Research Article
DOI: 10.1039/C8QO01379A
Citation: Org. Chem. Front., 2019, Advance Article

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    Fischernolides A–D, four novel diterpene-based meroterpenoid scaffolds with antitumor activities from Euphorbia fischeriana

    J. Zhang, J. He, Y. Cheng, P. Zhang, Y. Yan, H. Zhang, W. Zhang and J. Xu, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C8QO01379A

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