Issue 14, 2019

Fischernolides A–D, four novel diterpene-based meroterpenoid scaffolds with antitumor activities from Euphorbia fischeriana

Abstract

Fischernolides A–D (1–4), four meroterpenoids based on diterpene and acylphloroglucinol, possessing an unprecedented 28-carbon skeleton with a novel scaffold, were isolated from the roots of Euphorbia fischeriana. Their structures and absolute configurations were determined by comprehensive chemical analyses including spectroscopic techniques, electronic circular dichroism (ECD) spectroscopy, and single crystal X-ray diffraction experiments. The possible biogenetic pathway to generate 1–4 through aldol condensation was also proposed. Compound 2 showed significant cytotoxicity and can induce the apoptosis of MCF-7 and Bel-7402 cell lines by caspase activation.

Graphical abstract: Fischernolides A–D, four novel diterpene-based meroterpenoid scaffolds with antitumor activities from Euphorbia fischeriana

Supplementary files

Article information

Article type
Research Article
Submitted
20 Dec 2018
Accepted
09 Feb 2019
First published
15 Feb 2019

Org. Chem. Front., 2019,6, 2312-2318

Fischernolides A–D, four novel diterpene-based meroterpenoid scaffolds with antitumor activities from Euphorbia fischeriana

J. Zhang, J. He, Y. Cheng, P. Zhang, Y. Yan, H. Zhang, W. Zhang and J. Xu, Org. Chem. Front., 2019, 6, 2312 DOI: 10.1039/C8QO01379A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements