Issue 10, 2019

Synthesis of chiral seven-membered cyclic sulfonamides through palladium-catalyzed arylation of cyclic imines

Abstract

An enantioselective palladium-catalyzed addition of arylboronic acids to seven-membered cyclic N-sulfonyl aldimines and ketimines has been developed, giving the chiral cyclic sulfonamides with excellent yields and up to 99% ee.

Graphical abstract: Synthesis of chiral seven-membered cyclic sulfonamides through palladium-catalyzed arylation of cyclic imines

Supplementary files

Article information

Article type
Research Article
Submitted
08 Dec 2018
Accepted
20 Mar 2019
First published
22 Mar 2019

Org. Chem. Front., 2019,6, 1572-1576

Synthesis of chiral seven-membered cyclic sulfonamides through palladium-catalyzed arylation of cyclic imines

Z. Zhao, L. Shi, F. Meng, Y. Li and Y. Zhou, Org. Chem. Front., 2019, 6, 1572 DOI: 10.1039/C8QO01323C

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