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Issue 9, 2019
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Chemoselective N-arylation of aminobenzene sulfonamides via copper catalysed Chan–Evans–Lam reactions

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Abstract

Cu-Catalysed Chan–Evans–Lam cross-coupling reactions between unprotected aminobenzene sulfonamides and arylboron nucleophiles are explored herein. Chemoselective N-arylation of aminobenzene sulfonamides could be simply enabled by the adjustment of reaction variables, such as the sources of aerobic oxidative Cu catalysis, solvents and bases. The arylation processes could be well regulated to occur on either amino or sulfonamide nitrogen atoms at room temperature under open flask conditions.

Graphical abstract: Chemoselective N-arylation of aminobenzene sulfonamides via copper catalysed Chan–Evans–Lam reactions

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Publication details

The article was received on 06 Dec 2018, accepted on 16 Jan 2019 and first published on 17 Jan 2019


Article type: Research Article
DOI: 10.1039/C8QO01313F
Org. Chem. Front., 2019,6, 1356-1360

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    Chemoselective N-arylation of aminobenzene sulfonamides via copper catalysed Chan–Evans–Lam reactions

    W. Zu, S. Liu, X. Jia and L. Xu, Org. Chem. Front., 2019, 6, 1356
    DOI: 10.1039/C8QO01313F

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