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Trifluoromethyl-substituted selenium ylide: a broadly applicable electrophilic trifluoromethylating reagent

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Abstract

The preparation of an easily available, air/moisture insensitive electrophilic reagent, trifluoromethyl-substituted selenium ylide 1a, and its reactions with a variety of nucleophiles including β-ketoesters and silyl enol ethers, aryl/heteroaryl boronic acids, electron-rich heteroarenes and sulfinates were described. These results suggest that reagent 1a is a broadly applicable electrophilic trifluoromethylating reagent.

Graphical abstract: Trifluoromethyl-substituted selenium ylide: a broadly applicable electrophilic trifluoromethylating reagent

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Publication details

The article was received on 16 Nov 2018, accepted on 03 Jan 2019 and first published on 05 Jan 2019


Article type: Research Article
DOI: 10.1039/C8QO01249K
Citation: Org. Chem. Front., 2019, Advance Article

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    Trifluoromethyl-substituted selenium ylide: a broadly applicable electrophilic trifluoromethylating reagent

    H. Ge and Q. Shen, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C8QO01249K

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