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Copper-catalyzed regioselective cyclization of vinyl azides by gem-difluoromethylene for trisubstituted pyridines

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Abstract

A novel copper-catalyzed cyclization of readily available vinyl azides with gem-difluoromethylene is described. This protocol is highly efficient and regioselective for assembling diverse trisubstituted pyridines in good to excellent yields, in which gem-difluoromethylene acted as a C1 precursor with a carbonyl group via triple cleavage and vinyl azides played a pivotal dual role.

Graphical abstract: Copper-catalyzed regioselective cyclization of vinyl azides by gem-difluoromethylene for trisubstituted pyridines

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Publication details

The article was received on 09 Nov 2018, accepted on 21 Dec 2018 and first published on 31 Dec 2018


Article type: Research Article
DOI: 10.1039/C8QO01212A
Citation: Org. Chem. Front., 2019, Advance Article
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    Copper-catalyzed regioselective cyclization of vinyl azides by gem-difluoromethylene for trisubstituted pyridines

    Z. Liu, G. Zhu, W. Gao, L. Yang, H. Ji, L. Tong and B. Tang, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C8QO01212A

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