Issue 5, 2019

Synergistic promotion by intramolecular hydrogen bonding: a bi-functionally catalyzed cascade reaction for the synthesis of enantiopure chromenopyrrolidines

Abstract

An effective organocatalytic asymmetric cascade reaction of o-hydroxy aromatic aldimines and β,γ-unsaturated-α-ketoesters was developed. Intramolecular hydrogen-bonding activation promoted the generation of fused ring frameworks which bear four contiguous stereocenters including one quaternary stereocenter in one-pot operation with excellent yields and stereoselectivities.

Graphical abstract: Synergistic promotion by intramolecular hydrogen bonding: a bi-functionally catalyzed cascade reaction for the synthesis of enantiopure chromenopyrrolidines

Supplementary files

Article information

Article type
Research Article
Submitted
08 Nov 2018
Accepted
16 Jan 2019
First published
19 Jan 2019

Org. Chem. Front., 2019,6, 674-678

Synergistic promotion by intramolecular hydrogen bonding: a bi-functionally catalyzed cascade reaction for the synthesis of enantiopure chromenopyrrolidines

J. Cao, J. Liu, Y. Zhang, Z. Wang and P. Xu, Org. Chem. Front., 2019, 6, 674 DOI: 10.1039/C8QO01208C

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