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Synergistic promotion by intramolecular hydrogen bonding: a bi-functionally catalyzed cascade reaction for the synthesis of enantiopure chromenopyrrolidines

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Abstract

An effective organocatalytic asymmetric cascade reaction of o-hydroxy aromatic aldimines and β,γ-unsaturated-α-ketoesters was developed. Intramolecular hydrogen-bonding activation promoted the generation of fused ring frameworks which bear four contiguous stereocenters including one quaternary stereocenter in one-pot operation with excellent yields and stereoselectivities.

Graphical abstract: Synergistic promotion by intramolecular hydrogen bonding: a bi-functionally catalyzed cascade reaction for the synthesis of enantiopure chromenopyrrolidines

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Publication details

The article was received on 08 Nov 2018, accepted on 16 Jan 2019 and first published on 19 Jan 2019


Article type: Research Article
DOI: 10.1039/C8QO01208C
Citation: Org. Chem. Front., 2019, Advance Article

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    Synergistic promotion by intramolecular hydrogen bonding: a bi-functionally catalyzed cascade reaction for the synthesis of enantiopure chromenopyrrolidines

    J. Cao, J. Liu, Y. Zhang, Z. Wang and P. Xu, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C8QO01208C

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