Jump to main content
Jump to site search

Issue 5, 2019
Previous Article Next Article

Synergistic promotion by intramolecular hydrogen bonding: a bi-functionally catalyzed cascade reaction for the synthesis of enantiopure chromenopyrrolidines

Author affiliations

Abstract

An effective organocatalytic asymmetric cascade reaction of o-hydroxy aromatic aldimines and β,γ-unsaturated-α-ketoesters was developed. Intramolecular hydrogen-bonding activation promoted the generation of fused ring frameworks which bear four contiguous stereocenters including one quaternary stereocenter in one-pot operation with excellent yields and stereoselectivities.

Graphical abstract: Synergistic promotion by intramolecular hydrogen bonding: a bi-functionally catalyzed cascade reaction for the synthesis of enantiopure chromenopyrrolidines

Back to tab navigation

Supplementary files

Publication details

The article was received on 08 Nov 2018, accepted on 16 Jan 2019 and first published on 19 Jan 2019


Article type: Research Article
DOI: 10.1039/C8QO01208C
Citation: Org. Chem. Front., 2019,6, 674-678

  •   Request permissions

    Synergistic promotion by intramolecular hydrogen bonding: a bi-functionally catalyzed cascade reaction for the synthesis of enantiopure chromenopyrrolidines

    J. Cao, J. Liu, Y. Zhang, Z. Wang and P. Xu, Org. Chem. Front., 2019, 6, 674
    DOI: 10.1039/C8QO01208C

Search articles by author

Spotlight

Advertisements