Issue 5, 2019

Cu/Pd-Catalyzed chemoselective synthesis of C-3 dicarbonyl indoles and bis(indolyl)alkanes from aldehydes and indoles

Abstract

A novel and efficient Cu/Pd-catalyzed chemoselective synthesis of C-3 dicarbonyl indoles and bis(indolyl)alkanes from aldehydes and indoles has been achieved. High selectivity for two valuable indole derivatives is achieved by allowing the same substrates to go through different reaction pathways catalyzed by different metal catalysts. Moreover, this mild process affords a wide range of substrates scope and has a high efficacy in large-scale reactions. A plausible mechanism is proposed based on the control experiments.

Graphical abstract: Cu/Pd-Catalyzed chemoselective synthesis of C-3 dicarbonyl indoles and bis(indolyl)alkanes from aldehydes and indoles

Supplementary files

Article information

Article type
Research Article
Submitted
07 Nov 2018
Accepted
09 Jan 2019
First published
10 Jan 2019

Org. Chem. Front., 2019,6, 627-631

Cu/Pd-Catalyzed chemoselective synthesis of C-3 dicarbonyl indoles and bis(indolyl)alkanes from aldehydes and indoles

S. Guo, Z. Fang, B. Zhou, J. Hua, Z. Dai, Z. Yang, C. Liu, W. He and K. Guo, Org. Chem. Front., 2019, 6, 627 DOI: 10.1039/C8QO01206G

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