Jump to main content
Jump to site search


A concise approach for determining the relative configuration of H-7 and H-8 in 8,4′-oxyneolignans by 1H NMR spectroscopy

Author affiliations

Abstract

The determination of molecular configuration is usually a difficult and key point in the structure elucidation of natural products. However, due to the small number of available samples and the multiple chiral centers and complex structures of natural products, it is difficult to rapidly and accurately determine their relative configurations. In this paper, we use an NMR technique to comprehensively study 8,4′-oxyneolignan glucosides and find that the chemical shift difference between H-9a and H-9b can be used to accurately and rapidly determine the relative configuration of H-7 and H-8. Our finding can be directly applied to 8,4′-oxyneolignan glucosides without the need for hydrolysis.

Graphical abstract: A concise approach for determining the relative configuration of H-7 and H-8 in 8,4′-oxyneolignans by 1H NMR spectroscopy

Back to tab navigation

Supplementary files

Publication details

The article was received on 25 Oct 2018, accepted on 22 Nov 2018 and first published on 23 Nov 2018


Article type: Research Article
DOI: 10.1039/C8QO01155A
Citation: Org. Chem. Front., 2019, Advance Article
  •   Request permissions

    A concise approach for determining the relative configuration of H-7 and H-8 in 8,4′-oxyneolignans by 1H NMR spectroscopy

    Y. Yang, B. Han, P. Yang, Z. Feng, J. Jiang and P. Zhang, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C8QO01155A

Search articles by author

Spotlight

Advertisements