Issue 3, 2019
From the journal:

Organic Chemistry Frontiers

Rapid access to difluoroalkylated pyrrolobenzodiazepines via a Pd-catalyzed C–H difluoroalkylation/cyclization cascade reaction†

Yang Gao,abc   Chunpu Li, ORCID logo *bc   Bin Xu ORCID logo a  and  Hong Liu ORCID logo *bc  

* Corresponding authors

a Department of Chemistry, Shanghai University, Shanghai 200444, China

b State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, China
E-mail: lichunpu@simm.ac.cn, hliu@simm.ac.cn

c Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, China

Abstract

An efficient approach to difluoroalkylated pyrrolobenzodiazepines has been developed using a Pd-catalyzed two-component C–H difluoroalkylation/cyclization cascade reaction. This protocol constitutes a straightforward route for the synthesis of difluoroalkylated pyrrolobenzodiazepine derivatives in good yields with excellent functional group tolerance.

Graphical abstract: Rapid access to difluoroalkylated pyrrolobenzodiazepines via a Pd-catalyzed C–H difluoroalkylation/cyclization cascade reaction

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Article information

DOI
https://doi.org/10.1039/C8QO01154K
Article type
Research Article
Submitted
25 Oct 2018
Accepted
20 Dec 2018
First published
08 Jan 2019

Org. Chem. Front., 2019,6, 410-414

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Rapid access to difluoroalkylated pyrrolobenzodiazepines via a Pd-catalyzed C–H difluoroalkylation/cyclization cascade reaction

Y. Gao, C. Li, B. Xu and H. Liu, Org. Chem. Front., 2019, 6, 410 DOI: 10.1039/C8QO01154K

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