Jump to main content
Jump to site search

Issue 4, 2019
Previous Article Next Article

Synthesis of 2-acetyl trisubstituted furans via copper-mediated deacylation cleavage of unstrained C(sp3)–C(sp2) bonds

Author affiliations

Abstract

A simple and convenient approach for the construction of 2-acetyl trisubstituted furans with acetylenic ketones and 1,3-dicarbonyl compounds via Cu-mediated unstrained C(sp3)–C(sp2) bond cleavage has been described. Mechanistic studies indicate that this transformation proceeds via a sequence of addition, cyclization, and C–C bond cleavage to afford the corresponding products in moderate to good yields.

Graphical abstract: Synthesis of 2-acetyl trisubstituted furans via copper-mediated deacylation cleavage of unstrained C(sp3)–C(sp2) bonds

Back to tab navigation

Supplementary files

Publication details

The article was received on 22 Oct 2018, accepted on 23 Dec 2018 and first published on 25 Dec 2018


Article type: Research Article
DOI: 10.1039/C8QO01139G
Citation: Org. Chem. Front., 2019,6, 437-441

  •   Request permissions

    Synthesis of 2-acetyl trisubstituted furans via copper-mediated deacylation cleavage of unstrained C(sp3)–C(sp2) bonds

    J. Fan, S. Wang, J. Chen, M. Wu, J. Zhang and M. Xie, Org. Chem. Front., 2019, 6, 437
    DOI: 10.1039/C8QO01139G

Search articles by author

Spotlight

Advertisements