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Synthesis of 2-acetyl trisubstituted furans via copper-mediated deacylation cleavage of unstrained C(sp3)–C(sp2) bonds

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Abstract

A simple and convenient approach for the construction of 2-acetyl trisubstituted furans with acetylenic ketones and 1,3-dicarbonyl compounds via Cu-mediated unstrained C(sp3)–C(sp2) bond cleavage has been described. Mechanistic studies indicate that this transformation proceeds via a sequence of addition, cyclization, and C–C bond cleavage to afford the corresponding products in moderate to good yields.

Graphical abstract: Synthesis of 2-acetyl trisubstituted furans via copper-mediated deacylation cleavage of unstrained C(sp3)–C(sp2) bonds

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Publication details

The article was received on 22 Oct 2018, accepted on 23 Dec 2018 and first published on 25 Dec 2018


Article type: Research Article
DOI: 10.1039/C8QO01139G
Citation: Org. Chem. Front., 2019, Advance Article
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    Synthesis of 2-acetyl trisubstituted furans via copper-mediated deacylation cleavage of unstrained C(sp3)–C(sp2) bonds

    J. Fan, S. Wang, J. Chen, M. Wu, J. Zhang and M. Xie, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C8QO01139G

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