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Issue 2, 2019
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AgBF4-catalyzed deoxygenative C2-amination of quinoline N-oxides with isothiocyanates

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Abstract

A general, effective and convenient protocol for the direct synthesis of various 2-aminoquinolines (39 examples) through AgBF4-catalyzed amination of quinoline N-oxides with isothiocyanates under base-, oxidant-free and mild conditions was developed. The transformation could be performed on a gram-scale and in a sequential manner starting from quinoline N-oxide to the synthesis of benzo[4,5]imidazo[1,2-a]quinoline.

Graphical abstract: AgBF4-catalyzed deoxygenative C2-amination of quinoline N-oxides with isothiocyanates

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Publication details

The article was received on 18 Oct 2018, accepted on 15 Nov 2018 and first published on 16 Nov 2018


Article type: Research Article
DOI: 10.1039/C8QO01128A
Citation: Org. Chem. Front., 2019,6, 167-171

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    AgBF4-catalyzed deoxygenative C2-amination of quinoline N-oxides with isothiocyanates

    L. Xie, S. Peng, L. Jiang, X. Peng, W. Xia, X. Yu, X. Wang, Z. Cao and W. He, Org. Chem. Front., 2019, 6, 167
    DOI: 10.1039/C8QO01128A

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