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Issue 2, 2019
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Visible-light-mediated direct synthesis of phosphorotrithioates as potent anti-inflammatory agents from white phosphorus

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Abstract

A light-promoted phosphorylation of thiols from P4 is described. The reaction of P4 with arylthiols in the presence of Na2–eosin Y under visible light gave phosphorotrithioites. Subsequent oxidation of phosphorotrithioites produced phosphorotrithioates. The phosphorotrithioate 3f presents good inflammation reducing characteristics.

Graphical abstract: Visible-light-mediated direct synthesis of phosphorotrithioates as potent anti-inflammatory agents from white phosphorus

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Publication details

The article was received on 10 Oct 2018, accepted on 16 Nov 2018 and first published on 16 Nov 2018


Article type: Research Article
DOI: 10.1039/C8QO01087K
Citation: Org. Chem. Front., 2019,6, 190-194

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    Visible-light-mediated direct synthesis of phosphorotrithioates as potent anti-inflammatory agents from white phosphorus

    G. Lu, J. Chen, X. Huangfu, X. Li, M. Fang, G. Tang and Y. Zhao, Org. Chem. Front., 2019, 6, 190
    DOI: 10.1039/C8QO01087K

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