Jump to main content
Jump to site search


Unprecedented thiocarbamidation of nitroarenes: a facile one-pot route to unsymmetrical thioureas

Author affiliations

Abstract

Aromatic nitro compounds undergo one-pot thiocarbamide functionalization upon reacting with in situ generated dithiocarbamate anions in the presence of K2CO3 and DMF solvent to produce unsymmetrical thiourea compounds in good yields. Various cyclic and acyclic 2° amines, 1° amines, and aromatic amines reacted with CS2 to form dithiocarbamate anions which combine with different nitroarenes resulting in the formation of thiourea compounds. The reaction is assumed to proceed through a nitrosobenzene intermediate.

Graphical abstract: Unprecedented thiocarbamidation of nitroarenes: a facile one-pot route to unsymmetrical thioureas

Back to tab navigation

Supplementary files

Publication details

The article was received on 23 Jul 2018, accepted on 16 Nov 2018 and first published on 19 Nov 2018


Article type: Research Article
DOI: 10.1039/C8QO00752G
Citation: Org. Chem. Front., 2019, Advance Article
  •   Request permissions

    Unprecedented thiocarbamidation of nitroarenes: a facile one-pot route to unsymmetrical thioureas

    S. Dutta, M. Mondal, T. Ghosh and A. Saha, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C8QO00752G

Search articles by author

Spotlight

Advertisements