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Stable supramolecular porphyrin@albumin nanoparticles for optimal photothermal activity

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Abstract

Porphyrins and their derivatives have been widely exerted as potential phototherapeutic nanomaterials in biomedical fields because of their favorable biocompatibility as well as easy chemical modification. However, the intrinsic hydrophobic properties still limit their further clinical translation. Albumin has been developed as a promising carrier for chemotherapeutic and protein drugs. Except for enhanced water solubility, using human serum albumin (HSA) endows efficient cellular internalization, prolonged blood circulation time, intensive tissue penetration depth and favorable pharmacokinetics and biodistribution. Herein, we constructed supramolecular nanoparticles (HSA–porphyrin SNPs) by the rational assembly of hexadecyl chain bonded porphyrin with HSA in a 1 : 1 stoichiometry via a tight non-covalent interaction. The as-prepared SNPs exhibited robust photostability, a high photothermal conversion efficiency of 45% and recycled utilization. The SNPs can be endocytosed effectively, thus eliciting superb cancer cell inhibition in vitro and thermal ablation of tumors in vivo under illumination. We believe that this study can offer a new horizon to understand the interaction of small molecules with HSA, which highlights the opportunity to explore the next-generation HSA-binding nanomedicine for future cancer precision therapy.

Graphical abstract: Stable supramolecular porphyrin@albumin nanoparticles for optimal photothermal activity

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Publication details

The article was received on 13 Jun 2019, accepted on 21 Jul 2019 and first published on 22 Jul 2019


Article type: Research Article
DOI: 10.1039/C9QM00387H
Mater. Chem. Front., 2019, Advance Article

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    Stable supramolecular porphyrin@albumin nanoparticles for optimal photothermal activity

    X. Zheng, L. Wang, Z. Lei, Q. Pei, S. Liu and Z. Xie, Mater. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QM00387H

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