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Issue 9, 2019
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Zinc porphyrin–polydopamine core–shell nanostructures for enhanced photodynamic/photothermal cancer therapy

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Abstract

Multimodal therapy, integrating two or more compositions with different functions into a nanoplatform, will generate the synergistic effects of the multi-components and effectively improve the tumor therapeutic efficacy. Herein, core–shell structured ZnP@PDA nanoparticles (NPs) were easily constructed via encapsulating the near-infrared (NIR) photosensitizer of zinc porphyrin nanoparticles (ZnP NPs) with polydopamine (PDA). The ZnP@PDA NPs displayed good biocompatibility and could effectively prevent aggregation after intravenous injection. Triggered by a NIR laser, the ZnP@PDA NPs exhibited excellent photodynamic performance. Furthermore, compared with PDA or ZnP NPs, the ZnP@PDA NPs showed improved photothermal performance with a high photothermal conversion efficiency (PCE) of 46.8% due to the triplet exciton quenching and fluorescence resonance energy transfer (FRET). In vitro and in vivo evaluations demonstrated that the ZnP@PDA NPs could directly target the tumor site via the enhanced permeability and retention (EPR) effect and exhibited strong phototoxicity and outstanding tumor phototherapeutic efficacy.

Graphical abstract: Zinc porphyrin–polydopamine core–shell nanostructures for enhanced photodynamic/photothermal cancer therapy

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Publication details

The article was received on 30 Mar 2019, accepted on 21 Jun 2019 and first published on 21 Jun 2019


Article type: Research Article
DOI: 10.1039/C9QM00197B
Mater. Chem. Front., 2019,3, 1786-1792

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    Zinc porphyrin–polydopamine core–shell nanostructures for enhanced photodynamic/photothermal cancer therapy

    C. Ou, Y. Zhang, D. Pan, K. Ding, S. Zhang, W. Xu, W. Wang, W. Si, Z. Yang and X. Dong, Mater. Chem. Front., 2019, 3, 1786
    DOI: 10.1039/C9QM00197B

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