Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 22nd May 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.



NIR triphenylamine grafted BODIPY derivative with high photothermal conversion efficiency and singlet oxygen generation for imaging guided phototherapy

Abstract

Osteosarcoma, the most common malignant bone tissue tumor, with high degree of malignancy, strong metastasis, and early lung metastasis, can result in extremely high mortality, which is a serious threat to human health. Boron dipyrromethene (BODIPY) compounds have shown great potential in photodynamic tumor therapy. In this study, an NIR triphenylamine grafted BODIPY derivative (BDPTPA) with high singlet oxygen generation efficiency (35.2%) was designed and synthesized. BDPTPA nanoparticles (NPs) obtained by nanoprecipitation present high photothermal conversion efficiency (52.6%). Both MTT assay and flow cytometry experiments suggest that BDPTPA NPs are able to generate high photo-toxicity and induce apoptosis of osteosarcoma cells, while present negligible dark-toxicity towards osteosarcoma cells as well as normal human cells. Cell migration and transwell experiments demonstrate that BDPTPA NPs can inhibit the migration of osteosarcoma cells. Due to the enhanced permeability and retention (EPR) effects, BDPTPA NPs can accumulate in tumor tissue in 6 h. Pharmacokinetic study in rats indicate that BDPTPA NPs eliminate much more slowly than BDPTPA in 10% DMSO. Under the irradiation of 808 nm laser, In vivo experiments, BDPTPA NPs can significantly inhibit tumor growth without side effects towards normal tissues. BDPTPA NPs shows good biosafety and excellent therapeutic effect both in vitro and in vivo, indicating their great potential for treatment of osteosarcoma.

Back to tab navigation

Supplementary files

Publication details

The article was received on 26 Jan 2019, accepted on 10 May 2019 and first published on 17 May 2019


Article type: Research Article
DOI: 10.1039/C9QM00044E
Mater. Chem. Front., 2019, Accepted Manuscript

  •   Request permissions

    NIR triphenylamine grafted BODIPY derivative with high photothermal conversion efficiency and singlet oxygen generation for imaging guided phototherapy

    J. Zhu, J. Zou, Z. Zhang, J. Zhang, Y. Sun, X. Dong and Q. Zhang, Mater. Chem. Front., 2019, Accepted Manuscript , DOI: 10.1039/C9QM00044E

Search articles by author

Spotlight

Advertisements