Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 2, 2019
Previous Article Next Article

A versatile catalyst-free perfluoroaryl azide–aldehyde–amine conjugation reaction

Author affiliations

Abstract

In a tri-component reaction, an electrophilically-activated perfluoroaryl azide, an enolizable aldehyde and an amine react readily at room temperature without any catalysts in solvents including aqueous conditions to yield a stable amidine conjugate. The versatility of this reaction is demonstrated in the conjugation of an amino acid without prior protection of the carboxyl group, and in the synthesis of antibiotic–nanoparticle conjugates.

Graphical abstract: A versatile catalyst-free perfluoroaryl azide–aldehyde–amine conjugation reaction

Back to tab navigation

Supplementary files

Publication details

The article was received on 10 Oct 2018, accepted on 30 Nov 2018 and first published on 04 Dec 2018


Article type: Research Article
DOI: 10.1039/C8QM00516H
Citation: Mater. Chem. Front., 2019,3, 251-256

  •   Request permissions

    A versatile catalyst-free perfluoroaryl azide–aldehyde–amine conjugation reaction

    S. Xie, J. Zhou, X. Chen, N. Kong, Y. Fan, Y. Zhang, G. Hammer, D. G. Castner, O. Ramström and M. Yan, Mater. Chem. Front., 2019, 3, 251
    DOI: 10.1039/C8QM00516H

Search articles by author

Spotlight

Advertisements