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A facile metal–phenolic–amine strategy for dual-functionalization of blood-contacting devices with antibacterial and anticoagulant properties

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Abstract

Thrombosis and infections of extracorporeal circuits and indwelling medical devices are the two major life-threatening complications faced in clinical practice. Herein, we report a novel and facile metal–phenolic–amine surface modification strategy to engineer a multifunctional coating on these devices to combat thrombosis and infection. This strategy is inspired by the metal–catecholamine coordination complex of [Fe(dopa)3] in mussels, in which Cu(II) ions (metal), plant polyphenol gallic acid (phenol) and cystamine (amine) are employed to fabricate a copper–phenolic–amine network. Our in vitro and in vivo experiments reveal that the resultant Cu(II)-chelating coatings endow the modified tubing with not only durable antibacterial properties, but also capability to persistently generate anticoagulant therapeutic nitric oxide (NO) gas in the presence of endogenous S-nitrosothiols (RSNO) from fresh blood. We anticipate that our simple and multifunctional coating strategy will be a milestone in the development of surface engineering, especially that of biomedical devices.

Graphical abstract: A facile metal–phenolic–amine strategy for dual-functionalization of blood-contacting devices with antibacterial and anticoagulant properties

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Publication details

The article was received on 11 Sep 2018, accepted on 11 Dec 2018 and first published on 12 Dec 2018


Article type: Research Article
DOI: 10.1039/C8QM00458G
Citation: Mater. Chem. Front., 2019, Advance Article
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    A facile metal–phenolic–amine strategy for dual-functionalization of blood-contacting devices with antibacterial and anticoagulant properties

    Q. Tu, X. Shen, Y. Liu, Q. Zhang, X. Zhao, M. F. Maitz, T. Liu, H. Qiu, J. Wang, N. Huang and Z. Yang, Mater. Chem. Front., 2019, Advance Article , DOI: 10.1039/C8QM00458G

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