Jump to main content
Jump to site search


A quinoline-based probe for effective and selective sensing of aspartic acid in aqueous medium: in vitro and in vivo live cell imaging

Author affiliations

Abstract

A naturally occurring nitrogen heterocycle-based Schiff base sensor 8-methyl-2-oxo-1,2-dihydroquinoline-3-carboxaldehyde-4N-phenylsemicarbazone (8MPS) was synthesized; a highly sensitive and selective “on–off–on” chemosensor for aspartic acid in aqueous solution was established. In vitro live cell imaging of 8MPS, 8MPSC and 8MPSCA against human breast cancer cells and in vivo imaging using C. elegans as a model have been successfully demonstrated. The sensing probe (8MPS) showed enhanced green fluorescence.

Graphical abstract: A quinoline-based probe for effective and selective sensing of aspartic acid in aqueous medium: in vitro and in vivo live cell imaging

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Aug 2019, accepted on 16 Sep 2019 and first published on 18 Sep 2019


Article type: Research Article
DOI: 10.1039/C9QI00992B
Inorg. Chem. Front., 2019, Advance Article

  •   Request permissions

    A quinoline-based probe for effective and selective sensing of aspartic acid in aqueous medium: in vitro and in vivo live cell imaging

    C. Elamathi, R. J. Butcher, A. Mohankumar, P. Sundararaj, A. Madankumar, P. Kalaivani and R. Prabhakaran, Inorg. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QI00992B

Search articles by author

Spotlight

Advertisements