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Novel osmium(II)–cymene complexes containing curcumin and bisdemethoxycurcumin ligands

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Abstract

The first examples of (arene)Os(II) curcuminoid derivatives have been prepared and characterized. The neutral complexes [(p-cym)Os(curc)Cl] (1) and [(p-cym)Os(bdcurc)Cl] (2), together with the cationic derivatives [(p-cym)Os(curc)(PTA)][SO3CF3] (3) and [(p-cym)Os(bdcurc)(PTA)][SO3CF3] (4) (PTA = 1,3,5-triaza-7-phosphaadamantane) were characterized by NMR spectroscopy and ESI mass spectrometry, and the crystal structure of 1 was determined by X-ray diffraction analysis. The cytotoxicity of the complexes was evaluated in vitro against human ovarian carcinoma cells (A2780 and A2780cisR), as well as against non-tumorous Human Embryonic Kidney cells (HEK293). Binding of the complexes to potential pharmacological targets and serum carriers was also explored.

Graphical abstract: Novel osmium(ii)–cymene complexes containing curcumin and bisdemethoxycurcumin ligands

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Publication details

The article was received on 09 Jul 2019, accepted on 06 Aug 2019 and first published on 13 Aug 2019


Article type: Research Article
DOI: 10.1039/C9QI00843H
Inorg. Chem. Front., 2019, Advance Article

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    Novel osmium(II)–cymene complexes containing curcumin and bisdemethoxycurcumin ligands

    R. Pettinari, F. Marchetti, C. Di Nicola, C. Pettinari, M. Cuccioloni, L. Bonfili, A. M. Eleuteri, B. Therrien, L. K. Batchelor and P. J. Dyson, Inorg. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QI00843H

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