Jump to main content
Jump to site search


Copper(II) facilitated decarboxylation for the construction of pyridyl–pyrazole skeletons

Author affiliations

Abstract

A highly simple and practical method was explored for the synthesis of pyridyl–pyrazole carboxylic compounds in one step by Cu(II) facilitated decarboxylation of 3,5-pyrazole-dicarboxylic acid (H3pdc) in pyridine–water. The activation of pyridine was induced by a hydroxyl radical, originating from the homolytic cleavage of the pz-COO bond, and thereafter transfer of the radical to water. Mechanistic studies showed that the elongation of the CuII–Ocarboxyl bond in the side cores of [Cu3(pdc)2(py)6(H2O)2] (1) promoted the generation of reactive radicals through decarboxylation. A possible reaction mechanism was proposed, involving a radical-induced pyridine C–H bond activation and a copper-facilitated pyridyl–pyrazole C–N bond formation.

Graphical abstract: Copper(ii) facilitated decarboxylation for the construction of pyridyl–pyrazole skeletons

Back to tab navigation

Supplementary files

Publication details

The article was received on 24 May 2019, accepted on 21 Jul 2019 and first published on 22 Jul 2019


Article type: Research Article
DOI: 10.1039/C9QI00599D
Inorg. Chem. Front., 2019, Advance Article

  •   Request permissions

    Copper(II) facilitated decarboxylation for the construction of pyridyl–pyrazole skeletons

    S. Xiang, X. Zhang, H. Chen, Y. Li, W. Fan and D. Huang, Inorg. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QI00599D

Search articles by author

Spotlight

Advertisements