Synergistic Design of Tin Phosphate Entrapped Graphene Flakes Nanocomposite as an Efficient Catalyst for the Electrochemical Determination of Antituberculosis Drug Isoniazid in Biological Samples
The rapid quantification of drugs in biological samples has turned the hottest issue and ongoing challenge to protect human health. To address this issue, we designed and synthesized a tin phosphate entrapped graphene flakes (SnP/GRF) nanocomposite for the trace level electrochemical detection of antituberculosis drug isoniazid (ISZ). Moreover, the successful formation of SnP/GRF nanocomposite was confirmed by various spectroscopic and analytical techniques. Based on the synergistic effect, the proposed electrode material exhibits excellent and superior electrochemical activity towards ISZ detection. The SnP/GRF nanocomposite modified electrode possesses a high electric conductivity and a good charge transfer process, which is highly desired for an advanced electrocatalyst. Benefiting from the fabricated SnP/GRF modified electrode, the ISZ sensing exhibited a wide dynamic working range (0.01–348 µM) and a low detection limit (1.0 nM) with an outstanding sensitivity (1.418 μA μM−1cm−2). More importantly, the SnP/GRF based electrochemical sensing system also has good storage stability, reliable reproducibility, rapid response time and high selectivity. Our proposed electrochemical sensor has the promising potential for the determination of ISZ in biological samples. Our work finding presents an innovative design to fabricate multifunctional catalyst for the versatile applications in the emerging next-generation electrochemical fields.