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Activatable Smart Nanoprobe for Sensitive Endogenous MMP2 Detection and Fluorescence Imaging Guided Phototherapies

Abstract

A stimuli-activatable theranostic system enabling selective imaging and controlled phototherapies is highly essential for precise cancer diagnosis and treatment. Herein, we designed a smart theranostic nanoprobe that was comprised of photosensitizer (PS), gold nanorods (AuNRs) and a matrix metalloproteinase 2 (MMP2) responsive peptide linker. Apart from being applied for photodynamic therapy (PDT), PS has also been widely used for fluorescence imaging. Spatiotemporal control of photoactivity of PS is of great importance for cancer theranostics. In the work, since the presence of Förster resonance energy transfer (FRET) between PS and AuNRs, the fluorescence and 1O2 production of PS were silenced during the circulation, avoiding adverse damage to normal tissue. While, the nanoprobe could be activated for targeted imaging and selective PDT when the peptide linker was cleaved by over-expressed MMP2 in cancer cells. More importantly, the restored fluorescence can be successfully used to quantitatively detect MMP2 with a detection limit of 29 pM and light up cancer cells, further guiding the synergistic activated PDT/PTT (photothermal therapy) for highly efficient and special killing cancer cells. This study helps to design smart cancer-related biomarkers-activatable theranostic probes for molecular sensing and site-specific cancer treatment.

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Publication details

The article was accepted on 08 Feb 2019 and first published on 11 Feb 2019


Article type: Research Article
DOI: 10.1039/C9QI00002J
Citation: Inorg. Chem. Front., 2019, Accepted Manuscript

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    Activatable Smart Nanoprobe for Sensitive Endogenous MMP2 Detection and Fluorescence Imaging Guided Phototherapies

    B. Hu, P. Li, Y. Zhang, C. Shan, P. Su, J. Cao, B. Cheng, W. Wu, W. Liu and Y. Tang, Inorg. Chem. Front., 2019, Accepted Manuscript , DOI: 10.1039/C9QI00002J

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