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Synchronous sensing of three conserved sequences of Zika virus using a DNAs@MOF hybrid: experimental and molecular simulation studies

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Abstract

A metal–organic framework of Cu(II) supported by a zwitterionic pyridinium dicarboxylate and 4,4′-bipyridine mixed ligands was prepared and impregnated with three dye-labeled DNA sequences with fixed wavelength differences. This hybrid material formed is capable of the synchronous detection of three conserved Zika virus RNA sequences with high sensitivity and selectivity, and low detection limits of 0.56 ± 0.02, 0.16 ± 0.04, and 0.19 ± 0.05 nM, without any cross-reactions, as confirmed by both experimental and molecular simulation studies.

Graphical abstract: Synchronous sensing of three conserved sequences of Zika virus using a DNAs@MOF hybrid: experimental and molecular simulation studies

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Publication details

The article was received on 26 Sep 2018, accepted on 12 Nov 2018 and first published on 13 Nov 2018


Article type: Research Article
DOI: 10.1039/C8QI01031E
Citation: Inorg. Chem. Front., 2019, Advance Article
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    Synchronous sensing of three conserved sequences of Zika virus using a DNAs@MOF hybrid: experimental and molecular simulation studies

    B. Xie, G. Qiu, B. Sun, Z. Yang, W. Zhang, J. Chen and Z. Jiang, Inorg. Chem. Front., 2019, Advance Article , DOI: 10.1039/C8QI01031E

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