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Melamine-mediated supramolecular assembly of nucleobase-modified poly(l-lysine)

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Abstract

Polypeptides serve as a bridge between natural macromolecules and synthetic polymers, leading to the development of biocompatible and biodegradable materials with diverse and complex structures. Here, nucleobase modified polylysine (PLL-co-PTLL) was synthesized via post-polymerization modification of polylysine with thymine (T). Then, melamine (M) with three thymine-like faces was taken as a molecular chaperone analogue to drive the self-assembly of PLL-co-PTLL. It was observed that 7M–1T (M : T = 7 : 1) was the appropriate molar ratio for the pronounced self-assembly, resulting in regular and uniform fibers with an extremely high aspect ratio when the substitution degree of T was relatively low (around 27%). Furthermore, the morphological transformation from fibrous to spherical could be achieved by simply increasing the substitution degree of T. We proposed that melamine and thymine could assemble into a tetrameric structure, which enabled the accumulation of polypeptide chains in a cooperative nucleation-growth polymerization mechanism. Therefore, multiple H-bonding faces created between designable substitution polypeptides and complementary molecules would promote synergistic and hierarchical self-assembly processes.

Graphical abstract: Melamine-mediated supramolecular assembly of nucleobase-modified poly(l-lysine)

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Publication details

The article was received on 19 Sep 2019, accepted on 05 Nov 2019 and first published on 06 Nov 2019


Article type: Paper
DOI: 10.1039/C9PY01413F
Polym. Chem., 2019, Advance Article

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    Melamine-mediated supramolecular assembly of nucleobase-modified poly(L-lysine)

    L. Zhu, Y. Xiao, J. Zhang, S. Zheng and M. Lang, Polym. Chem., 2019, Advance Article , DOI: 10.1039/C9PY01413F

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