Forcing single-chain nanoparticle collapse through hydrophobic solvent interactions in comb copolymers
We introduce a novel synthetic strategy in which high molecular weight aliphatic comb copolymers can collapse into single-chain nanoparticles (SNCPs) via photodimerization of anthracene under ultraviolet (UV) irradiation. By deliberately selecting hydrophobic comonomers with disparate solvency, we demonstrated that we could control chain collapse. We attribute these results to the formation of pseudo-unimicellar structures, whereby polyisobutylene (PIB) side chains are preferrentially solvated pushing anthracene moieties to form a denser crosslinked core. The control of hydrophobic interactions is a common occurrence in proteins and we believe that our approach can be further extended to achieve multi-compartment SCNPs whereby each section is responsible for a given function.
- This article is part of the themed collection: Polymer Chemistry Emerging Investigators