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Issue 31, 2019
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Controlling biofilm formation with nitroxide functional surfaces

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Bacterial biofilm formation on medical devices is a threat to healthcare systems worldwide as bacteria within a biofilm are more resistant to standard antimicrobial therapies. Herein, we introduce a nitroxide-based antibiofilm coating strategy, which is specifically designed to prevent biofilm formation of Gram-negative pathogens such as Pseudomonas aeruginosa. Nitroxide-decorated hydroxyapatite surfaces were readily prepared in an aqueous dip-coating procedure using a nitroxide-functionalized catecholamine as a polymerizable coating agent. Additional spatial control over the polymer surface deposition on titanium was gained by applying a photolithographic coating setup. All nitroxide-coated surfaces exhibited excellent antibiofilm properties toward PA14 surface colonization as biofilm formation was completely suppressed. Importantly, the surrounding adhesive polymer matrix did not interfere with the nitroxide-characteristic antibiofilm properties. The herein introduced platform technology represents a bioinspired and versatile coating approach, offering a safe and prophylactic avenue to combat biofilm contamination on a variety of surfaces.

Graphical abstract: Controlling biofilm formation with nitroxide functional surfaces

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Publication details

The article was received on 14 May 2019, accepted on 01 Jul 2019 and first published on 02 Jul 2019

Article type: Paper
DOI: 10.1039/C9PY00690G
Polym. Chem., 2019,10, 4252-4258

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    Controlling biofilm formation with nitroxide functional surfaces

    H. Woehlk, M. J. Trimble, S. C. Mansour, D. Pletzer, V. Trouillet, A. Welle, L. Barner, R. E. W. Hancock, C. Barner-Kowollik and K. E. Fairfull-Smith, Polym. Chem., 2019, 10, 4252
    DOI: 10.1039/C9PY00690G

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