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Issue 31, 2019
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Controlling biofilm formation with nitroxide functional surfaces

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Bacterial biofilm formation on medical devices is a threat to healthcare systems worldwide as bacteria within a biofilm are more resistant to standard antimicrobial therapies. Herein, we introduce a nitroxide-based antibiofilm coating strategy, which is specifically designed to prevent biofilm formation of Gram-negative pathogens such as Pseudomonas aeruginosa. Nitroxide-decorated hydroxyapatite surfaces were readily prepared in an aqueous dip-coating procedure using a nitroxide-functionalized catecholamine as a polymerizable coating agent. Additional spatial control over the polymer surface deposition on titanium was gained by applying a photolithographic coating setup. All nitroxide-coated surfaces exhibited excellent antibiofilm properties toward PA14 surface colonization as biofilm formation was completely suppressed. Importantly, the surrounding adhesive polymer matrix did not interfere with the nitroxide-characteristic antibiofilm properties. The herein introduced platform technology represents a bioinspired and versatile coating approach, offering a safe and prophylactic avenue to combat biofilm contamination on a variety of surfaces.

Graphical abstract: Controlling biofilm formation with nitroxide functional surfaces

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Supplementary files

Article information

14 May 2019
01 Jul 2019
First published
02 Jul 2019

Polym. Chem., 2019,10, 4252-4258
Article type

Controlling biofilm formation with nitroxide functional surfaces

H. Woehlk, M. J. Trimble, S. C. Mansour, D. Pletzer, V. Trouillet, A. Welle, L. Barner, R. E. W. Hancock, C. Barner-Kowollik and K. E. Fairfull-Smith, Polym. Chem., 2019, 10, 4252
DOI: 10.1039/C9PY00690G

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