Multi-stimuli responsive trigger for temporally controlled depolymerization of self-immolative polymers

For many decades, stimuli-responsive materials have been studied and utilized in various fields, ranging from chemical sensors to controlled drug release. Among these responsive materials are self-immolative polymers (SIPs) that allow for end-to-end depolymerization and the ability to release a desired cargo on demand or amplify analyte detection. However, in typical SIP systems, the triggering event leads to a relatively uncontrolled degradation process. Herein we present a multi-stimuli trigger that utilizes the combination of heat and acid to impart control over the trigger event and thus the degradation process. By controlling this reaction, we achieve temporal control over the trigger cleavage and subsequent depolymerization and release of cargo from the SIP.