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A perylenediimide-based nanocarrier monitors curcumin release with “off-on” fluorescence switch

Abstract

Perylenediimide-cored (PDI-cored) polymer has been widely applied as fluorescent drug carrier due to its high fluorescence quantum yield and outstanding chemical/photophysical stability. However, most of these delivery systems are lack of detailed drug delivery information, especially when and where the drug is released. In this study, a PDI-based nanocarrier (PPL-B) is constructed and applied to monitor curcumin release with “off-on” fluorescence switch. The star-shaped drug carrier has an amphiphilic structure with fluorescent PDI as core and poly(amino acid) as shell, which is suitable for drug delivery. A model drug curcumin is loaded to PPL-B and quenches its fluorescence significantly through photo-induced electron transfer (PET). Upon curcumin release, the fluorescence of PPL-B achieves “off-on” switch as a result of PET interruption. In light of this, curcumin release is successfully monitored by CUR@PPL-B at cellular level. This PDI-based nanocarrier for drug release monitoring with PET mechanism shows great potential in drug delivery field.

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Publication details

The article was received on 27 Jan 2019, accepted on 12 Apr 2019 and first published on 12 Apr 2019


Article type: Paper
DOI: 10.1039/C9PY00132H
Citation: Polym. Chem., 2019, Accepted Manuscript

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    A perylenediimide-based nanocarrier monitors curcumin release with “off-on” fluorescence switch

    W. Cheng, H. Chen, C. Ji , R. Yang and M. Yin, Polym. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C9PY00132H

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