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Multi-stimuli responsive poly(amidoamine) dendrimers with peripheral N-dialkylaminoethyl carbamate moieties

Qi-Song Tong,ab  Wei Xu,ab  Qiu-Yue Huang,b  Ya-Ru Zhang,b  Xiao-Xiao Shi,b  Hua Huang,ac  Hong-Jun Li,bc  Jin-Zhi Du*abd  and  Jun Wangabefd 
Author affiliations

* Corresponding authors

a School of Biomedical Science and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou 510006, China
E-mail: djzhi@scut.edu.cn

b Institutes for Life Sciences, and School of Medicine, South China University of Technology, Guangzhou, China

c Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou 510006, China

d Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510005, China

e National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, China

f Key Laboratory of Biomedical Engineering of Guangdong Province, South China University of Technology, Guangzhou 510006, China

Abstract

A novel type of multi-stimuli responsive dendrimer with thermo-, pH-, and CO2-responsiveness was developed through facile modification of polyamidoamine dendrimers (PAMAM) with various N-dialkylaminoethyl carbamate moieties. A series of modified PAMAM dendrimers with a well controlled structure were obtained and characterized by 1H NMR. The aqueous solutions of these dendrimers showed a lower critical solution temperature (LCST)-type thermoresponse, and their cloud point temperature (Tcp) was determined by turbidity measurements. Tcp was tunable from 8 to 70 °C, depending on the hydrophobicity and substitution number of the terminal N-dialkylaminoethyl groups, PAMAM generation, pH values, and salt concentrations. Additionally, the solubility of the resultant dendrimers could be reversibly modulated by alternately bubbling CO2 and argon. Our study offers a simple but effective approach to making new multi-stimuli responsive dendrimers for potential smart material applications.

Graphical abstract: Multi-stimuli responsive poly(amidoamine) dendrimers with peripheral N-dialkylaminoethyl carbamate moieties

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Publication details

The article was received on 13 Nov 2018, accepted on 27 Dec 2018 and first published on 28 Dec 2018


Article type: Paper
DOI: 10.1039/C8PY01605D
Citation: Polym. Chem., 2019, Advance Article
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    Multi-stimuli responsive poly(amidoamine) dendrimers with peripheral N-dialkylaminoethyl carbamate moieties

    Q. Tong, W. Xu, Q. Huang, Y. Zhang, X. Shi, H. Huang, H. Li, J. Du and J. Wang, Polym. Chem., 2019, Advance Article , DOI: 10.1039/C8PY01605D

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