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Optimizing the Cu-RDRP of N-(2-hydroxypropyl) methacrylamide toward biomedical applications

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Abstract

Aqueous Cu-RDRP of N-(2-hydroxypropyl) methacrylamide, a monomer with important biomedical applications, was optimized with respect to monomer conversion (82–99%), product dispersity (<1.25), and molecular weight control (up to 100 000). For this purpose, different chlorine-based initiators in conjunction with the CuCl/CuCl2/PMDETA catalytic system were used. The utility of the optimized method in the biomedical field was demonstrated in the preparation of the poly(HPMA)-based copolymeric carrier having the anti-cancer drug doxorubicin conjugated through a pH-sensitive hydrazone linker.

Graphical abstract: Optimizing the Cu-RDRP of N-(2-hydroxypropyl) methacrylamide toward biomedical applications

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Publication details

The article was received on 05 Nov 2018, accepted on 06 Dec 2018 and first published on 07 Dec 2018


Article type: Communication
DOI: 10.1039/C8PY01569D
Citation: Polym. Chem., 2019, Advance Article
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    Optimizing the Cu-RDRP of N-(2-hydroxypropyl) methacrylamide toward biomedical applications

    V. Raus and L. Kostka, Polym. Chem., 2019, Advance Article , DOI: 10.1039/C8PY01569D

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