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Strategies from nature: polycaprolactone-based mimetic antimicrobial peptide block copolymers with low cytotoxicity and excellent antibacterial efficiency

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Abstract

The resistance of bacteria to antibiotics has caused serious threats to public health and it is urgent to develop novel antibacterial agents that do not induce drug resistance. Herein, a series of novel antibacterial copolymers, PCL16-b-Kn, mimicking the structure and action mechanism of natural antimicrobial peptides is reported. The diblock copolymers were synthesized via ring-opening polymerization and facile coupling reaction. The antibacterial results confirmed that the diblock copolymers possess superior antibacterial activities and exhibit rapid bactericidal action against both S. aureus and E. coli. A conclusion can be drawn that the antibacterial activity can be promoted by achieving a balance between the cationic and hydrophobic segments in the copolymers. Further hemolysis and cytotoxicity tests suggest the excellent biocompatibility of these diblock copolymers. Overall, our synthetic strategy demonstrates a new concept of designing novel biocompatible antibacterial copolymers and expands the categories of next-generation antibacterial agents without inducing drug resistance.

Graphical abstract: Strategies from nature: polycaprolactone-based mimetic antimicrobial peptide block copolymers with low cytotoxicity and excellent antibacterial efficiency

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Publication details

The article was received on 28 Sep 2018, accepted on 20 Dec 2018 and first published on 27 Dec 2018


Article type: Paper
DOI: 10.1039/C8PY01394B
Citation: Polym. Chem., 2019, Advance Article

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    Strategies from nature: polycaprolactone-based mimetic antimicrobial peptide block copolymers with low cytotoxicity and excellent antibacterial efficiency

    X. Zhou, J. He and C. Zhou, Polym. Chem., 2019, Advance Article , DOI: 10.1039/C8PY01394B

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