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Synthesis of multifunctional miktoarm star polymers via an RGD peptide-based RAFT agent

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Abstract

Miktoarm star (MAS) polymers are polymers with a number of distinct arms connected to a central core. Owing to their exclusive structure, MAS polymers have been extensively studied in recent years. To exploit their biomedical applications the combination of nucleic acids, peptides and saccharides are desired. In this study, RAFT polymerization of three monomers with markedly different properties, N,N-dimethylaminoethyl methacrylate (DMAEMA, cationic), n-butyl methacrylate (BMA, hydrophobic) and oligo(ethylene glycol) methyl ether methacrylate (OEGMA, hydrophilic) was conducted using an RGD peptide based RAFT agent as a chain transfer agent (RGD-CTA). With a disulphide dimethacrylate (DSDMA) redox-cleavable cross-linker, the above linear polymers were combined via an “arm-first” technique to access MAS polymers containing peptide arms. These MAS polymers showed excellent biocompatibility, cell staining performance and rapid redox responsiveness. The novel MAS polymers have potential as a prospective platform for intracellular drug/gene delivery for cancer therapy.

Graphical abstract: Synthesis of multifunctional miktoarm star polymers via an RGD peptide-based RAFT agent

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Publication details

The article was received on 18 Sep 2018, accepted on 18 Nov 2018 and first published on 20 Nov 2018


Article type: Paper
DOI: 10.1039/C8PY01355A
Citation: Polym. Chem., 2019, Advance Article
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    Synthesis of multifunctional miktoarm star polymers via an RGD peptide-based RAFT agent

    C. Chen, X. Guo, J. Du, B. Choi, H. Tang, A. Feng and S. H. Thang, Polym. Chem., 2019, Advance Article , DOI: 10.1039/C8PY01355A

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