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Poly(butyl cyanoacrylate) nanoparticle containing an organic photoCORM

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Abstract

Carbon monoxide (CO) is a gasotransmitter, which has shown therapeutic effects in recent studies. Photo carbon monoxide releasing molecules (PhotoCORMs) allow the delivery of CO to be controlled by light. In this work, a new organic photoCORM DK4 is studied. DK4 is a diketone type photoCORM, which releases two CO molecules under visible light and simultaneously generates a fluorescent anthracene derivative. However, this type of CORM suffers from a deactivating hydration reaction and often needs to be incorporated in polymers or micelles. The two highly hydrophobic tert-butyl groups of DK4 protect it from the hydration reaction. DK4 functions in 1% DMSO aqueous solution, in which other DKs are deactivated. DK4 was incorporated in a poly(butyl cyanoacrylate) (PBCA) nanoparticle. PBCA has been used as a tissue adhesive and has been extensively studied for delivery of drugs to the brain. The PBCA/DK4 nanoparticle showed good photoactivity and low cytotoxicity, and thus is a promising material for studying the biomedical effects of CO.

Graphical abstract: Poly(butyl cyanoacrylate) nanoparticle containing an organic photoCORM

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Publication details

The article was received on 05 Jul 2019, accepted on 06 Sep 2019 and first published on 06 Sep 2019


Article type: Paper
DOI: 10.1039/C9PP00287A
Photochem. Photobiol. Sci., 2019, Advance Article

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    Poly(butyl cyanoacrylate) nanoparticle containing an organic photoCORM

    A. Elgattar, K. S. Washington, S. Talebzadeh, A. Alwagdani, T. Khalil, O. Alghazwat, S. Alshammri, H. Pal, C. Bashur and Y. Liao, Photochem. Photobiol. Sci., 2019, Advance Article , DOI: 10.1039/C9PP00287A

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