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Issue 8, 2019
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Synthesis and photodynamic effects of new porphyrin/4-oxoquinoline derivatives in the inactivation of S. aureus

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Abstract

New porphyrin/4-oxoquinoline conjugates were synthesized from the Heck coupling reaction of a β-brominated porphyrin with 1-allyl-4-oxoquinoline derivatives, followed by demetallation and deprotection affording the promising photosensitizers 9a–e. Singlet oxygen studies have demonstrated that all the porphyrin/4-oxoquinoline conjugates 9a–e were capable of producing cytotoxic species and found to be excellent photosensitizing agents in the inactivation of S. aureus by the antimicrobial photodynamic therapy (aPDT) protocol.

Graphical abstract: Synthesis and photodynamic effects of new porphyrin/4-oxoquinoline derivatives in the inactivation of S. aureus

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Article information


Submitted
28 Feb 2019
Accepted
08 Jul 2019
First published
09 Jul 2019

Photochem. Photobiol. Sci., 2019,18, 1910-1922
Article type
Paper

Synthesis and photodynamic effects of new porphyrin/4-oxoquinoline derivatives in the inactivation of S. aureus

F. S. Sagrillo, C. Dias, A. T. P. C. Gomes, M. A. F. Faustino, A. Almeida, A. Gonçalves de Souza, A. R. P. Costa, F. D. C. S. Boechat, M. C. Bastos Vieira de Souza, M. G. P. M. S. Neves and J. A. S. Cavaleiro, Photochem. Photobiol. Sci., 2019, 18, 1910
DOI: 10.1039/C9PP00102F

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