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Core–shell polymeric nanoparticles comprising BODIPY and fluorescein as ultra-bright ratiometric fluorescent pH sensors

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Abstract

A new ratiometric fluorescent pH nanosensor is presented. It is based on ultrabright nanoparticles containing two spatially separated fluorophores: BODIPY covalently linked to the polystyrene core and fluorescein grafted to the nanoparticle shell. The nanoparticles comprise a large number (≥2500) of both fluorescent moieties. Their spectroscopic characteristics were studied at different pH and ionic strength. They could successfully be used to determine the solution pH between 5.5 and 7.5 by measuring the fluorescence intensity ratio of the sensor molecule (fluorescein) relative to the reference dye (BODIPY).

Graphical abstract: Core–shell polymeric nanoparticles comprising BODIPY and fluorescein as ultra-bright ratiometric fluorescent pH sensors

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Publication details

The article was received on 12 Oct 2018, accepted on 18 Feb 2019 and first published on 19 Feb 2019


Article type: Paper
DOI: 10.1039/C8PP00457A
Citation: Photochem. Photobiol. Sci., 2019, Advance Article

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    Core–shell polymeric nanoparticles comprising BODIPY and fluorescein as ultra-bright ratiometric fluorescent pH sensors

    C. Grazon, Y. Si, J. Placial, J. Rieger, R. Méallet-Renault and G. Clavier, Photochem. Photobiol. Sci., 2019, Advance Article , DOI: 10.1039/C8PP00457A

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