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Issue 5, 2019
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Core–shell polymeric nanoparticles comprising BODIPY and fluorescein as ultra-bright ratiometric fluorescent pH sensors

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Abstract

A new ratiometric fluorescent pH nanosensor is presented. It is based on ultrabright nanoparticles containing two spatially separated fluorophores: BODIPY covalently linked to the polystyrene core and fluorescein grafted to the nanoparticle shell. The nanoparticles comprise a large number (≥2500) of both fluorescent moieties. Their spectroscopic characteristics were studied at different pH and ionic strength. They could successfully be used to determine the solution pH between 5.5 and 7.5 by measuring the fluorescence intensity ratio of the sensor molecule (fluorescein) relative to the reference dye (BODIPY).

Graphical abstract: Core–shell polymeric nanoparticles comprising BODIPY and fluorescein as ultra-bright ratiometric fluorescent pH sensors

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Supplementary files

Article information


Submitted
12 Oct 2018
Accepted
18 Feb 2019
First published
19 Feb 2019

Photochem. Photobiol. Sci., 2019,18, 1156-1165
Article type
Paper

Core–shell polymeric nanoparticles comprising BODIPY and fluorescein as ultra-bright ratiometric fluorescent pH sensors

C. Grazon, Y. Si, J. Placial, J. Rieger, R. Méallet-Renault and G. Clavier, Photochem. Photobiol. Sci., 2019, 18, 1156
DOI: 10.1039/C8PP00457A

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