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Issue 5, 2019
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Depth resolved label-free multimodal optical imaging platform to study morpho-molecular composition of tissue

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Abstract

Multimodal imaging platforms offer a vast array of tissue information in a single image acquisition by combining complementary imaging techniques. By merging different systems, better tissue characterization can be achieved than is possible by the constituent imaging modalities alone. The combination of optical coherence tomography (OCT) with non-linear optical imaging (NLOI) techniques such as two-photon excited fluorescence (TPEF), second harmonic generation (SHG) and coherent anti-Stokes Raman scattering (CARS) provides access to detailed information of tissue structure and molecular composition in a fast, label-free and non-invasive manner. We introduce a multimodal label-free approach for morpho-molecular imaging and spectroscopy and validate the system in mouse skin demonstrating the potential of the system for colocalized acquisition of OCT and NLOI signals.

Graphical abstract: Depth resolved label-free multimodal optical imaging platform to study morpho-molecular composition of tissue

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Publication details

The article was received on 18 Sep 2018, accepted on 08 Jan 2019 and first published on 18 Mar 2019


Article type: Paper
DOI: 10.1039/C8PP00410B
Photochem. Photobiol. Sci., 2019,18, 997-1008
  • Open access: Creative Commons BY license
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    Depth resolved label-free multimodal optical imaging platform to study morpho-molecular composition of tissue

    M. Andreana, R. Sentosa, M. T. Erkkilä, W. Drexler and A. Unterhuber, Photochem. Photobiol. Sci., 2019, 18, 997
    DOI: 10.1039/C8PP00410B

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