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Stabilisation of lipid membrane-incorporated porphyrin derivative aqueous solutions and their photodynamic activities

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Abstract

Lipid membrane-incorporated porphyrin derivatives (LMIPors) having three phenyl moieties and one pyridyl or pyridinium moiety at the meso-positions were more stable than LMIPors having phenyl and/or pyridyl moieties. The former two LMIPors showed high photodynamic activity toward cancer cells under photoirradiation at wavelengths over 600 nm, which are the most suitable for photodynamic therapy. The photodynamic activities were greater than that of Photofrin, which is currently the main drug employed clinically as a photosensitiser. The results represent significant progress toward the optimisation of LMIPors as photosensitisers.

Graphical abstract: Stabilisation of lipid membrane-incorporated porphyrin derivative aqueous solutions and their photodynamic activities

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Publication details

The article was received on 30 Jul 2018, accepted on 19 Nov 2018 and first published on 20 Nov 2018


Article type: Paper
DOI: 10.1039/C8PP00350E
Citation: Photochem. Photobiol. Sci., 2019, Advance Article
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    Stabilisation of lipid membrane-incorporated porphyrin derivative aqueous solutions and their photodynamic activities

    T. Nakaya, B. Horiguchi, S. Hino, K. Sugikawa, H. Funabashi, A. Kuroda and A. Ikeda, Photochem. Photobiol. Sci., 2019, Advance Article , DOI: 10.1039/C8PP00350E

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