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In situ intravenous photodynamic therapy for the systemic eradication of blood stream infections

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Abstract

Photodynamic therapy is one of the most promising non-invasive strategies employed for the treatment of several kinds of bacterial infections. Though the vast majority of clinically approved photosensitisers are administered intravenously, most of the in vitro experiments are performed under static conditions which do not represent the physiological environment of the venous bloodstream. To address this issue, a dynamic circulation model was developed to facilitate in situ antibacterial photodynamic therapy under flow conditions to mimic blood stream infections.

Graphical abstract: In situ intravenous photodynamic therapy for the systemic eradication of blood stream infections

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Publication details

The article was received on 25 Jun 2018, accepted on 18 Dec 2018 and first published on 20 Dec 2018


Article type: Communication
DOI: 10.1039/C8PP00267C
Citation: Photochem. Photobiol. Sci., 2019, Advance Article
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    In situ intravenous photodynamic therapy for the systemic eradication of blood stream infections

    M. Raschpichler, M. R. Agel, S. R. Pinnapireddy, L. Duse, E. Baghdan, J. Schäfer and U. Bakowsky, Photochem. Photobiol. Sci., 2019, Advance Article , DOI: 10.1039/C8PP00267C

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