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Synthesis, photochemical and in vitro cytotoxic evaluation of benzoselenazole-based aminosquaraines

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Abstract

Squaraine dyes have recently attracted interest as potential second generation photosensitizers for photodynamic therapy. Several cationic aminosquaraine dyes bearing benzoselenazole terminal nuclei were synthezised and their cytotoxic activity was tested against four different human tumor cell lines – breast (MCF-7), non-small cell lung (NCI-H460), cervical (HeLa) and hepatocellular (HepG2) carcinomas – and against a non-tumor porcine liver primary cell line (PLP2), both in the absence of light and under irradiation. All dyes, which displayed strong absorption within the phototherapeutic window, were found to exhibit photodynamic activity and were shown to be, in most cases, more cytotoxic, both in the dark and upon irradiation, than their benzothiazole analogues.

Graphical abstract: Synthesis, photochemical and in vitro cytotoxic evaluation of benzoselenazole-based aminosquaraines

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Publication details

The article was received on 10 May 2018, accepted on 19 Sep 2018 and first published on 24 Sep 2018


Article type: Paper
DOI: 10.1039/C8PP00201K
Citation: Photochem. Photobiol. Sci., 2019, Advance Article
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    Synthesis, photochemical and in vitro cytotoxic evaluation of benzoselenazole-based aminosquaraines

    Á. F. Magalhães, V. C. Graça, R. C. Calhelha, I. L. Ferreira Machado, L. F. Vieira Ferreira, I. C. F. R. Ferreira and P. F. Santos, Photochem. Photobiol. Sci., 2019, Advance Article , DOI: 10.1039/C8PP00201K

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