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A hybrid polymer to target blood group dependence of cholera toxin

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Abstract

Cholera is a potentially fatal bacterial infection caused by the cholera toxin (CT), an AB5 toxin secreted by Vibrio cholera. GM1 has long been known as the receptor of the cholera toxin in the intestine. However, increasing evidence is pointing towards the role of fucosylated conjugates as additional attachment options of the toxin. In the present paper we have synthesized a polymeric hybrid which can inhibit both modes of attachment.

Graphical abstract: A hybrid polymer to target blood group dependence of cholera toxin

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Publication details

The article was received on 01 Nov 2019, accepted on 28 Nov 2019 and first published on 28 Nov 2019


Article type: Communication
DOI: 10.1039/C9OB02369K
Org. Biomol. Chem., 2020, Advance Article
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    A hybrid polymer to target blood group dependence of cholera toxin

    D. Haksar, L. Quarles van Ufford and R. J. Pieters, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/C9OB02369K

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