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Issue 48, 2019
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Manganese-catalyzed cascade annulations of alkyne-tethered N-alkoxyamides: synthesis of polycyclic isoquinolin-1(2H)-ones

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Abstract

A strategy for the synthesis of isoxazolidine/1,2-oxazinane-fused isoquinolin-1(2H)-ones from alkyne-tethered N-alkoxyamides is described, in which cheap Mn(acac)2 is used as a catalyst to facilitate a radical cascade annulation. The method features mild conditions, additive-free reaction and broad substrate scope. It is the first example via manganese/air catalytic systems to construct isoquinolin-1(2H)-one heterocycles.

Graphical abstract: Manganese-catalyzed cascade annulations of alkyne-tethered N-alkoxyamides: synthesis of polycyclic isoquinolin-1(2H)-ones

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Supplementary files

Article information


Submitted
01 Nov 2019
Accepted
21 Nov 2019
First published
21 Nov 2019

Org. Biomol. Chem., 2019,17, 10167-10171
Article type
Communication

Manganese-catalyzed cascade annulations of alkyne-tethered N-alkoxyamides: synthesis of polycyclic isoquinolin-1(2H)-ones

G. Kong, J. Han, D. Yang, J. Niu and M. Song, Org. Biomol. Chem., 2019, 17, 10167
DOI: 10.1039/C9OB02364J

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