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Molecular replication using covalent base-pairs with traceless linkers

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Abstract

A unique feature of kinetically inert covalent base-pairing is that the nature of the chemical information that is transferred can be modulated by changing the chemical connectivity between the two bases. Formation of esters between phenols and benzoic acids has been used as a base-pairing strategy for sequence information transfer in template-directed synthesis of linear oligomers, but the copy strand produced by this process has the complementary sequence to the template strand. It is possible to form a base-pair between two benzoic acids by using a hydroquinone linker, which is eliminated when the product duplex is hydrolysed. Using this approach, covalent template-directed synthesis was carried out using a benzoic acid 3-mer template to produce an identical copy. This direct replication process was used in iterative rounds of replication leading to an increase of the population of the copied oligomer.

Graphical abstract: Molecular replication using covalent base-pairs with traceless linkers

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Publication details

The article was received on 20 Sep 2019, accepted on 29 Oct 2019 and first published on 06 Nov 2019


Article type: Paper
DOI: 10.1039/C9OB02336D
Org. Biomol. Chem., 2019, Advance Article

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    Molecular replication using covalent base-pairs with traceless linkers

    D. Núñez-Villanueva and C. A. Hunter, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C9OB02336D

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