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Peroxide-mediated site-specific C-H methylation of imidazo[1,2-a]pyridines and quinoxalin-2(1H)-ones under metal-free condition

Abstract

An effective approach to realize the direct methylation of imidazo[1,2-a]pyridines and quinoxalin-2(1H)-ones with peroxides under metal-free condition is described. In this protocol, peroxides serve as both the radical initiator and methyl source. Methylated imidazopyridines and quinoxalin-2(1H)-ones were smoothly synthesized in moderate to good yields. A free radical reaction mechanism was proposed to describe the methylation process.

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Publication details

The article was received on 28 Oct 2019, accepted on 28 Nov 2019 and first published on 28 Nov 2019


Article type: Communication
DOI: 10.1039/C9OB02328C
Org. Biomol. Chem., 2019, Accepted Manuscript

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    Peroxide-mediated site-specific C-H methylation of imidazo[1,2-a]pyridines and quinoxalin-2(1H)-ones under metal-free condition

    S. Jin, H. Yao, S. Lin, X. You, Y. Yang and Z. Yan, Org. Biomol. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C9OB02328C

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