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A rhodium-catalysed three-component reaction to access C1-substituted tetrahydroisoquinolines

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Abstract

A rhodium-catalyzed three-component reaction of diazo compounds, anilines and C,N-cyclic azomethine imines via trapping of transient ammonium ylides was developed. This reaction provided a simple and convenient approach for the synthesis of pharmaceutically intriguing tetrahydroisoquinoline derivatives in moderate to good yields (36–85%) with good diastereoselectivities (up to 95 : 5 dr) under mild reaction conditions.

Graphical abstract: A rhodium-catalysed three-component reaction to access C1-substituted tetrahydroisoquinolines

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Publication details

The article was received on 24 Oct 2019, accepted on 08 Nov 2019 and first published on 08 Nov 2019


Article type: Communication
DOI: 10.1039/C9OB02303H
Org. Biomol. Chem., 2019, Advance Article

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    A rhodium-catalysed three-component reaction to access C1-substituted tetrahydroisoquinolines

    D. Zhang, J. Liu, Z. Kang, H. Qiu and W. Hu, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C9OB02303H

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