Issue 46, 2019

A rhodium-catalysed three-component reaction to access C1-substituted tetrahydroisoquinolines

Abstract

A rhodium-catalyzed three-component reaction of diazo compounds, anilines and C,N-cyclic azomethine imines via trapping of transient ammonium ylides was developed. This reaction provided a simple and convenient approach for the synthesis of pharmaceutically intriguing tetrahydroisoquinoline derivatives in moderate to good yields (36–85%) with good diastereoselectivities (up to 95 : 5 dr) under mild reaction conditions.

Graphical abstract: A rhodium-catalysed three-component reaction to access C1-substituted tetrahydroisoquinolines

Supplementary files

Article information

Article type
Communication
Submitted
24 Oct 2019
Accepted
08 Nov 2019
First published
08 Nov 2019

Org. Biomol. Chem., 2019,17, 9844-9848

A rhodium-catalysed three-component reaction to access C1-substituted tetrahydroisoquinolines

D. Zhang, J. Liu, Z. Kang, H. Qiu and W. Hu, Org. Biomol. Chem., 2019, 17, 9844 DOI: 10.1039/C9OB02303H

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